Administration of Oral Curcumin to Resistance Exercise after Immobilization Does Not Affect Skeletal Muscle Fiber Diameter in Rattus Norvegicus

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I Putu Alit Pawana
Martha Kurnia Kusumawardani
Lydia Arfianti

Abstract

ABSTRACTIntroduction: The aim of this study was to explore the effect of adding oral curcumin to resistance exerciseafter immobilization on the diameter of skeletal muscle fiber in Rattus Norvegicus.Methods: This was a post-test only study design on animal model. Subjects of the study were male Rattusnorvegicus strain Wistar, age 10-12 weeks old, weigh between 150-300 g, were immobilized at soleusmuscle for 2 weeks, then randomly allocated to 3 groups: (i) control group, (ii) resistance exercise, (iii)oral curcumin + resistance exercise. After 4 weeks of intervention, the diameter of the muscle fibers wasmeasured.Result: The results of this study showed a significant difference on the diameter of skeletal muscle fiberbetween control group and resistance exercise, as well as control group and resistance exercise + oralcurcumin (p<0.05). There was no significant difference between resistance exercise only and resistanceexercise + oral curcumin (p>0.05).Conclusion: Administration of oral curcumin to resistance exercise after immobilization does not affectskeletal muscle fiber diameter in Rattus Norvegicus.Keywords : curcumin, good health and well-being, immobilization, resist ance exercise, skeletal muscle.

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Author Biographies

I Putu Alit Pawana, Medical Staff

Department of Physical Medicine and Rehabilitation, Faculty of Medicine Universitas Airlangga, Dr.Soetomo General Academic Hospital, Surabaya, Indonesia

Martha Kurnia Kusumawardani, Medical Staff

Department of Physical Medicine and Rehabilitation, Faculty of Medicine Universitas Airlangga, Dr.Soetomo General Academic Hospital, Surabaya, Indonesia

Lydia Arfianti, Medical Staff

Department of Physical Medicine and Rehabilitation, Faculty of MedicineUniversitas Airlangga, Dr.Soetomo General Academic Hospital, Surabaya, Indonesia