Administration of Oral Curcumin to Resistance Exercise after Immobilization Does Not Affect Skeletal Muscle Fiber Diameter in Rattus Norvegicus
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Published:
Jun 1, 2022
Keywords:
curcumin, good health and well-being, immobilization, resist ance exercise, skeletal muscle.
Main Article Content
Abstract
ABSTRACTIntroduction: The aim of this study was to explore the effect of adding oral curcumin to resistance exerciseafter immobilization on the diameter of skeletal muscle fiber in Rattus Norvegicus.Methods: This was a post-test only study design on animal model. Subjects of the study were male Rattusnorvegicus strain Wistar, age 10-12 weeks old, weigh between 150-300 g, were immobilized at soleusmuscle for 2 weeks, then randomly allocated to 3 groups: (i) control group, (ii) resistance exercise, (iii)oral curcumin + resistance exercise. After 4 weeks of intervention, the diameter of the muscle fibers wasmeasured.Result: The results of this study showed a significant difference on the diameter of skeletal muscle fiberbetween control group and resistance exercise, as well as control group and resistance exercise + oralcurcumin (p<0.05). There was no significant difference between resistance exercise only and resistanceexercise + oral curcumin (p>0.05).Conclusion: Administration of oral curcumin to resistance exercise after immobilization does not affectskeletal muscle fiber diameter in Rattus Norvegicus.Keywords : curcumin, good health and well-being, immobilization, resist ance exercise, skeletal muscle.
Article Details
How to Cite
I Putu Alit Pawana, Martha Kurnia Kusumawardani, & Lydia Arfianti. (2022). Administration of Oral Curcumin to Resistance Exercise after Immobilization Does Not Affect Skeletal Muscle Fiber Diameter in Rattus Norvegicus. Indonesian Journal of Physical Medicine and Rehabilitation, 11(01), 50 - 57. https://doi.org/10.36803/ijpmr.v11i01.328
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Original Article
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References
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2. Appell H-J. Muscular atrophy following immobilization. Sport Med 1990; 10(1): 42–58. Figure 4. Example of a histopathological longitudinal cross section of soleus muscle from the resistance exercise group (Magnification x 400)Figure 5.Example of a histopathological cross-section of the soleus muscle from the resistance exercise group plus oral curcumin (Magnification x 400)
3. Atherton PJ, Greenhaff PL, Phillips SM, Bodine SC, Adams CM, Lang CH. Control of skeletal muscle atrophy in response to disuse: Clinical/preclinical contentions and fallacies of evidence. Am J Physiol - Endocrinol Metab 2016; 311(3): E594–604.
4. Jackman RW, Kandarian SC. The molecular basis of skeletal muscle atrophy. Am J Physiol Cell Physiol 2004; 287(4): C834–C843.
5. Gao Y, Arfat Y, Wang H, Goswami N. Muscle atrophy induced by mechanical unloading: Mechanisms and potential countermeasures. Front Physiol 2018; 9(3).
6. Rudrappa SS, Wilkinson DJ, Greenhaff PL, Smith K, Idris I, Atherton PJ. Human skeletal muscle disuse atrophy: Effects on muscle protein synthesis, breakdown, and insulin resistance-A qualitative review. Front Physiol 2016; 7(8): 1–10.
7. Hunter RB, Stevenson EJ, Koncarevic A, Mitchell-Felton H, Essig DA, Kandarian SC. Activation of an alternative NFâ€ÎšB pathway in skeletal muscle during disuse atrophy. FASEB J 2002; 16(6): 529–38.
8. Shim JS, Lee HJ, Park SS. Curcumin-induced apotosis of A-431 cells involves caspase-3 activation. J Biochem Mol Biol 2001; 34(3): 189-93.
9. Schmidt M, Weidemann A, Poser C, Bigot A, von Maltzahn J. Stimulation of non-canonical NF-κB through lymphotoxin-β-receptor impairs myogenic differentiation and regeneration of skeletal muscle. Front Cell Dev Biol 2021; 9(10): 1–17.
10. Bakkar N, Guttridge DC. NF-κB Signaling: A tale of two pathways in skeletal myogenesis. Physiol Rev 2010; 90(2): 495–511.
11. Bodine SC, Baehr LM. Skeletal muscle atrophy and the E3 ubiquitin ligases
MuRF1 and MAFbx/atrogin-1. Am J Physiol - Endocrinol Metab 2014; 307(6): E469–84.
12. Russell AP. Molecular regulation of skeletal muscle mass. Clin Exp Pharmacol 2010; 37(3): 378–84.
13. Receno CN, Liang C, Korol DL, Atalay M, Heffernan KS, Brutsaert TD, et al. Effects of prolonged dietary curcumin exposure on skeletal muscle biochemical and functional responses of aged male
rats. Int J Mol Sci 2019; 20(5): 1–18.
14. McCarthy JJ, Murach KA. Anabolic and catabolic signaling pathways that regulate skeletal muscle mass. Nutrition and enhanced sports performance: Muscle building, endurance and strength 2018: 275–290p.
15. Toigo M, Boutellier U. New fundamental resistance exercise determinants of
molecular and cellular muscle adaptations. Eur J Appl Physiol 2006; 97(6): 643–63.
16. Yin H, Price F, Rudnicki MA. Satellite cells and the muscle stem cell niche. Physiol Rev 2013; 93(1): 23–67.
17. Charge SBP, Rudnicki MA. Cellular and molecular regulation of muscle regeneration. Physiol Rev 2004; 84(1): 209–38.
18. Brisson BK, Spinazzola J, Park SH, Barton ER. Viral expression of insulin-
like growth factor I E-peptides increases skeletal muscle mass but at the expense of strength. Am J Physiol - Endocrinol Metab 2014; 306(8): 965–74.
19. Soebadi, Haryadi RD, Pawana IPA. Effect of oral curcumin and immobilization on the diameter of skeletal muscle fiber in rattus norvegicus. Folia Medica Indonesiana 2008; 44(1).
20. Tsai SW, Huang CC, Hsu YJ, Chen CJ, Lee PY, Huang YH, et al. Accelerated muscle recovery after in vivo curcumin supplementation. Nat Prod Commun 2020; 15(1): 1–9.
21. Pringga GA, Andriana RAM, Wardhani IL, Arfianti L. Comparison of hamstrings and quadriceps femoris muscle thickness increment between agonist-antagonist paired set and traditional set resistance training in untrained healthy subjects. Surabaya Phys Med Rehabil J 2021; 3(2): 60.