The Transition from Delayed Physiotherapy to Early Physiotherapy in Intensive Care Patients: A Bibliometric Analysis

Main Article Content

Atika Rahmah
Arsie Noor Rafidah
Yazid Azhari Utama
Yuanita Citra Syafitri
Farkhana Dwi Ariyanti
Wikha Aprian

Abstract

Introduction: Critically ill patients in the Intensive Care Unit (ICU) require timely and comprehensive interventions to ensure safety and optimize recovery. Early physiotherapy serves as a vital component of critical care, contributing to patients’ physical, psychological, and long-term functional recovery.
Methods: The study employed a bibliometric and systematic literature review to analyze research trends in early physiotherapy. Relevant articles were retrieved from SCOPUS-indexed journals, screened based on relevance, keywords, and abstracts, and analyzed using Mendeley for reference management and VOSviewer for bibliometric visualization.
Results: The analysis delineated six thematic clusters: (1) pathological classification and therapeutic modalities, (2) patient compliance, (3) therapeutic approaches, (4) physiotherapy in critical care settings, (5) condition-specific therapeutic methods, and (6) safety procedures. These clusters encapsulate the predominant research trajectories and focal domain within the corpus of early physiotherapy literature.
Conclusion: Early physiotherapy in critical care substantially enhances patients’ psychological well-being, physical functioning, and overall quality of life, while mitigating complications and reducing hospitalization costs. The findings highlight the importance of integrating early physiotherapy as an integral component of standardize ICU patient management.
Keywords: Patient, disease critical care, intensive care unit, early physiotherapy, bibliometric analysis
 

Article Details

How to Cite
Rahmah, A., Rafidah, A. N., Utama, Y. A., Syafitri, Y. C., Ariyanti, F. D., & Aprian, W. (2025). The Transition from Delayed Physiotherapy to Early Physiotherapy in Intensive Care Patients: A Bibliometric Analysis. Indonesian Journal of Physical Medicine and Rehabilitation, 14(2), 286 - 302. https://doi.org/10.36803/indojpmr.v14i2.451
Section
Literature Review
Author Biographies

Atika Rahmah

Faculty of Medicine, Sebelas Maret University, Indonesia

Arsie Noor Rafidah, Surakarta Central General Hospital

Surakarta Central General Hospital, Indonesia

Yazid Azhari Utama

Faculty of Medicine and Health Science, Muhammadiyah University of Yogyakarta, Indonesia

Yuanita Citra Syafitri

Faculty of Medicine, Sebelas Maret University, Indonesia

Farkhana Dwi Ariyanti

Buah Hati General Hospital Ciputat South Tangerang

Wikha Aprian

General Hospital Tamiang Layang, Barito Timur

References

1. Snelson C, Jones C, Atkins G, Hodson J, Whitehouse T, Veenith T, et al. A comparison of earlier and enhanced rehabilitation of mechanically ventilated patients in critical care compared to standard care (REHAB): Study protocol for a single-site randomised controlled feasibility trial. Pilot Feasibility Stud. 2017;3(1):1–9.
2. McWilliams D, Jones C, Atkins G, Hodson J, Whitehouse T, Veenith T, et al. Earlier and enhanced rehabilitation of mechanically ventilated patients in critical care: A feasibility randomised controlled trial. J Crit Care [Internet]. 2018;44:407–12. Available from: https://doi.org/10.1016/j.jcrc.2018.01.001
3. Santos LJ, Aguiar Lemos F, Bianchi T, Sachetti A, Acqua AMD, Silva Naue W, et al. Early rehabilitation using a passive cycle ergometer on muscle morphology in mechanically ventilated critically ill patients in the Intensive Care Unit (MoVe-ICU study): Study protocol for a randomized controlled trial. Trials [Internet]. 2015;16(1):4–9. Available from: http://dx.doi.org/10.1186/s13063-015-0914-8
4. Jolley SE, Dale CR, Hough CL. Hospital-level factors associated with report of physical activity in patients on mechanical ventilation across Washington State. Ann Am Thorac Soc. 2015;12(2):209–15.
5. Rollinson TC, Connolly B, Berlowitz DJ, Berney S. Physical activity of patients with critical illness undergoing rehabilitation in intensive care and on the acute ward: An observational cohort study. Aust Crit Care [Internet]. 2022;35(4):362–8. Available from: https://doi.org/10.1016/j.aucc.2021.06.005
6. Isyanto H, Muchtar H, Dinata AR. Design of Security System Device for Motorized Vehicles through the Telegram Messenger Application and Updating GPS Locations on Smartphones in Real Time with IoT-based Smart Vehicles. 2022;6(2):67–76.
7. Hiser S, Mantheiy E, Toonstra A, Friedman LA, Ramsay P, Needham DM. Physiotherapists’ and Physiotherapy Assistants’ Perspectives on Using Three Physical Function Measures in the Intensive Care Unit: A Mixed-Methods Study. Physiother Canada. 2022;74(3):240–6.
8. Rebel A, Marzano V, Green M, Johnston K, Wang J, Neeman T, et al. Mobilisation is feasible in intensive care patients receiving vasoactive therapy: An observational study. Aust Crit Care [Internet]. 2019;32(2):139–46. Available from: https://doi.org/10.1016/j.aucc.2018.03.004
9. Schmidt KFR, Huelle K, Reinhold T, Prescott HC, Gehringer R, Hartmann M, et al. Healthcare Utilization and Costs in Sepsis Survivors in Germany–Secondary Analysis of a Prospective Cohort Study. J Clin Med. 2022;11(4).
10. Furnari D, Khan N, Delaney M, Hamlaoui K, Lagree S, Peace A, et al. Brain, Lagree Method, Manual Therapy; Physical Exercise, Microformer, Massage in Psycho-Body, Emotional-Affective and Socio-Relational Recovery. J Addict Res. 2021;5(2):135–42.
11. Berney SC, Rose JW, Bernhardt J, Denehy L. Prospective observation of physical activity in critically ill patients who were intubated for more than 48 hours. J Crit Care [Internet]. 2015;30(4):658–63. Available from: http://dx.doi.org/10.1016/j.jcrc.2015.03.006
12. Morris PE, Berry MJ, Files DC, Thompson JC, Hauser J, Flores L, et al. Standardized rehabilitation and hospital length of stay among patients with acute respiratory failure a randomized clinical trial. JAMA - J Am Med Assoc [Internet]. 2016;315(24):2694–702. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976350801&doi=10.1001%2Fjama.2016.7201&partnerID=40&md5=7400ea78f9c0d56b0bfbfc6a85828e05
13. Eggmann S, Verra ML, Luder G, Takala J, Jakob SM. Effects of early, combined endurance and resistance training in mechanically ventilated, critically ill patients: A randomised controlled trial. PLoS One. 2018;13(11):1–19.
14. Bright L, Van Der Lee L, Hince D, Wood FM, Edgar DW. Quantification of the negative impact of sedation and inotropic support on achieving early mobility in burn patients in ICU: A single center observational study. Burns. 2021;47(8):1756–65.
15. Frazzitta G, Zivi I, Valsecchi R, Bonini S, Maffia S, Molatore K, et al. Effectiveness of a very early stepping verticalization protocol in severe acquired brain injured patients: A randomized pilot study in icu. PLoS One. 2016;11(7):1–15.
16. Qi W, Murphy TE, Doyle MM, Ferrante LE. associated Pneumonia among Critically Ill Patients. 2023;38(5):418–24.
17. Çakmak A, İnce Dİ, Sağlam M, Savcı S, Yağlı NV, Kütükcü EÇ, et al. Physiotherapy and rehabilitation implementation in intensive care units: A survey study. Turkish Thorac J. 2019;20(2):114–9.
18. Capell EL, Tipping CJ, Hodgson CL. Barriers to implementing expert safety recommendations for early mobilisation in intensive care unit during mechanical ventilation: A prospective observational study. Aust Crit Care [Internet]. 2019;32(3):185–90. Available from: https://doi.org/10.1016/j.aucc.2018.05.005
19. Holdsworth C, Haines KJ, Francis JJ, Marshall A, O’Connor D, Skinner EH. Mobilization of ventilated patients in the intensive care unit: An elicitation study using the theory of planned behavior. J Crit Care [Internet]. 2015;30(6):1243–50. Available from: http://dx.doi.org/10.1016/j.jcrc.2015.08.010
20. Barber EA, Everard T, Holland AE, Tipping C, Bradley SJ, Hodgson CL. Barriers and facilitators to early mobilisation in Intensive Care: A qualitative study. Aust Crit Care [Internet]. 2015;28(4):177–82. Available from: http://dx.doi.org/10.1016/j.aucc.2014.11.001
21. Hickmann CE, Castanares-Zapatero D, Bialais E, Dugernier J, Tordeur A, Colmant L, et al. Teamwork enables high level of early mobilization in critically ill patients. Ann Intensive Care. 2016;6(1).
22. Farley C, Newman ANL, Hoogenes J, Brooks D, Duffett M, Kho ME. Treatment Fidelity in 94 Randomized Controlled Trials of Physical Rehabilitation in the ICU: A Scoping Review∗. Crit Care Med. 2024;52(5):717–28.
23. Perme CS, Damasceno MS, Chandrashekar R, Xu J, Ratnani I, Masud F, et al. Perme ICU Physical Therapy Competency: Development of an ICU Knowledge and Skills Assessment Tool. Intensive Crit Care Nurs [Internet]. 2024;85(April):103750. Available from: https://doi.org/10.1016/j.iccn.2024.103750
24. Chiarici A, Andrenelli E, Serpilli O, Andreolini M, Tedesco S, Pomponio G, et al. An Early Tailored Approach Is the Key to Effective Rehabilitation in the Intensive Care Unit. Arch Phys Med Rehabil [Internet]. 2019;100(8):1506–14. Available from: https://doi.org/10.1016/j.apmr.2019.01.015
25. Sun J, Cui N, Han W, Li Q, Wang H, Li Z, et al. Implementation of Nurse-Led, Goal-Directed Lung Physiotherapy for Older Patients With Sepsis and Pneumonia in the ICU. Front Med. 2021;8(November):1–8.
26. Raios C, Keating JL, Skinner EH, Opdam HI, Haines KJ. Exploring current physiotherapy practices in the care of people who are potential lung donors: A qualitative study. Aust Crit Care [Internet]. 2024;37(4):539–47. Available from: https://doi.org/10.1016/j.aucc.2023.12.003
27. Rossi V, Santambrogio M, Del Monaco C, Retucci M, Tammaro S, Ceruti C, et al. Safety and feasibility of physiotherapy in ICU-admitted severe COVID-19 patients: An observational study. Monaldi Arch Chest Dis. 2022;92(4).
28. Candan SA, Elibol N, Abdullahi A. Consideration of prevention and management of long-term consequences of post-acute respiratory distress syndrome in patients with COVID-19. Physiother Theory Pract [Internet]. 2020;36(6):663–8. Available from: https://doi.org/10.1080/09593985.2020.1766181
29. Battaglini D, Caiffa S, Gasti G, Ciaravolo E, Robba C, Herrmann J, et al. An experimental pre-post study on the efficacy of respiratory physiotherapy in severe critically iii covid-19 patients. J Clin Med. 2021;10(10):1–12.
30. Patel BK, Pohlman AS, Hall JB, Kress JP. Impact of early mobilization on glycemic control and ICU-acquired weakness in critically ill patients who are mechanically ventilated. Chest. 2014;146(3):583–9.
31. Dong Z, Yu B, Zhang Q, Pei H, Xing J, Fang W, et al. Early rehabilitation therapy is beneficial for patients with prolonged mechanical ventilation after coronary artery bypass surgery a prospective random study. Int Heart J. 2016;57(2):241–6.
32. Windmöller P, Bodnar ET, Casagrande J, Dallazen F, Schneider J, Berwanger SA, et al. Physical exercise combined with cpap in subjects who underwent surgical myocardial revascularization: A randomized clinical trial. Respir Care. 2020;65(2):150–7.
33. Weeks A, Campbell C, Rajendram P, Shi W, Voigt LP. A Descriptive Report of Early Mobilization for Critically Ill Ventilated Patients with Cancer. Rehabil Oncol. 2017;35(3):144–50.
34. Wollersheim T, Haas K, Wolf S, Mai K, Spies C, Steinhagen-Thiessen E, et al. Whole-body vibration to prevent intensive care unit-acquired weakness: Safety, feasibility, and metabolic response. Crit Care [Internet]. 2017;21(1):1–10. Available from: http://dx.doi.org/10.1186/s13054-016-1576-y
35. de Cássia Artuni Rossi M, Corrêa TQ, Blanco KC, Bagnato VS, Salvio AG. Physiotherapy elastic band disinfection by UV-C irradiation in an intensive care unit. Photodiagnosis Photodyn Ther. 2021;34(March).
36. Burch D, Bernert S, Fraser JF. Increased physician and physical therapist communication is associated with earlier mobility and decreased length of stay in the cerebrovascular and trauma neuroscience population. NeuroRehabilitation. 2018;43(2):195–9.
37. Merino-Osorio C, Velásquez M, Reveco R, Marmolejo JI, Fu C. 24/7 Physical Therapy Intervention With Adult Patients in a Chilean Intensive Care Unit: A Cost-Benefit Analysis in a Developing Country. Value Heal Reg Issues [Internet]. 2020;23:99–104. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85095454059&doi=10.1016%2Fj.vhri.2020.04.006&partnerID=40&md5=d5f0ad7331b488809c44ea60bbcac9ac
38. Hayes E, Kalmakis KA. From the sidelines: Coaching as a nurse practitioner strategy for improving health outcomes. J Am Acad Nurse Pract. 2007;19(11):555–62.
39. Tronstad O, Martí JD, Ntoumenopoulos G, Gosselink R. An Update on Cardiorespiratory Physiotherapy during Mechanical Ventilation. Semin Respir Crit Care Med [Internet]. 2022;43(3):390–404. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129281807&doi=10.1055%2Fs-0042-1744307&partnerID=40&md5=18fed674056b1d7fdf258a9f9a7a45aa
40. Thomas P, Chaseling W, Marais L, Matheson C, Paton M, Swanepoel N. Physiotherapy services in intensive care. A workforce survey of Australia and New Zealand. Aust Crit Care [Internet]. 2023;36(5):806–12. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85144980280&doi=10.1016%2Fj.aucc.2022.11.004&partnerID=40&md5=ae065e7c2ecc9241a8b88cfe3b1f0ed5
41. Cebeci GC, Cebeci H, Kucuk MP, Kucuk AO, Bayrak IK, Ulger F. Neuromuscular Electrical Stimulator as a Protective Treatment against Intensive Care Unit Muscle Wasting in Sepsis/Septic Shock Patients. J Coll Physicians Surg Pakistan. 2022;32(10):1300–7.
42. Nickels MR, Aitken LM, Barnett AG, Walsham J, King S, Gale NE, et al. Effect of in-bed cycling on acute muscle wasting in critically ill adults: A randomised clinical trial. J Crit Care [Internet]. 2020;59:86–93. Available from: https://doi.org/10.1016/j.jcrc.2020.05.008
43. Zwoliński T, Wujtewicz M, Szamotulska J, Sinoracki T, Wąż P, Hansdorfer-Korzon R, et al. Feasibility of Chest Wall and Diaphragm Proprioceptive Neuromuscular Facilitation (PNF) Techniques in Mechanically Ventilated Patients. Int J Environ Res Public Health. 2022;19(2).
44. Vitacca M, Barbano L, Vanoglio F, Luisa A, Bernocchi P, Giordano A, et al. Does 6-month home caregiver-supervised physiotherapy improve post-critical care outcomes? Am J Phys Med Rehabil. 2016;95(8):571–9.
45. Wollersheim T, Grunow JJ, Carbon NM, Haas K, Malleike J, Ramme SF, et al. Muscle wasting and function after muscle activation and early protocol-based physiotherapy: an explorative trial. J Cachexia Sarcopenia Muscle. 2019;10(4):734–47.
46. Brummel NE, Girard TD, Ely EW, Pandharipande PP, Morandi A, Hughes CG, et al. Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: The Activity and Cognitive Therapy in ICU (ACT-ICU) trial. Intensive Care Med. 2014;40(3):370–9.
47. Zebuhr C, Sinha A, Skillman H, Buckvold S. Active Rehabilitation in a Pediatric Extracorporeal Membrane Oxygenation Patient. PM R [Internet]. 2014;6(5):456–60. Available from: http://dx.doi.org/10.1016/j.pmrj.2013.11.005
48. Nielsen RM, Olsen KS, Lauritsen AO, Boesen HC. Electroconvulsive therapy as a treatment for protracted refractory delirium in the intensive care unit-Five cases and a review. J Crit Care [Internet]. 2014;29(5):881.e1-881.e6. Available from: http://dx.doi.org/10.1016/j.jcrc.2014.05.012
49. Nickels MR, Aitken LM, Walsham J, Barnett AG, McPhail SM. Critical Care Cycling Study (CYCLIST) trial protocol: A randomised controlled trial of usual care plus additional in-bed cycling sessions versus usual care in the critically ill. BMJ Open [Internet]. 2017;7(10). Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032366537&doi=10.1136%2Fbmjopen-2017-017393&partnerID=40&md5=78924cdac0149673656d44b92715072c
50. Castro-Avila AC, Serón P, Fan E, Gaete M, Mickan S. Effect of early rehabilitation during intensive care unit stay on functional status: Systematic review and meta-analysis. PLoS One [Internet]. 2015;10(7). Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84940030301&doi=10.1371%2Fjournal.pone.0130722&partnerID=40&md5=69b4a2083963d33a0b76cde6bba841f1
51. Corner EJ, Hichens L V., Attrill KM, Vizcaychipi MP, Brett SJ, Handy JM. The responsiveness of the Chelsea Critical Care Physical Assessment tool in measuring functional recovery in the burns critical care population: An observational study. Burns [Internet]. 2015;41(2):241–7. Available from: http://dx.doi.org/10.1016/j.burns.2014.12.002
52. Chigira Y, Takai T, Igusa H, Dobashi K. Effects of early physiotherapy with respect to severity of pneumonia of elderly patients admitted to an intensive care unit: A single center study in Japan. J Phys Ther Sci [Internet]. 2015;27(7):2053–6. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937877266&doi=10.1589%2Fjpts.27.2053&partnerID=40&md5=90aac30e4f5ac1680c7aca5c2f1673af
53. Osseis M, Weyrech J, Gayat E, Dagois S, Lo Dico R, Pocard M, et al. Epidural analgesia combined with a comprehensive physiotherapy program after Cytoreductive Surgery and HIPEC is associated with enhanced post-operative recovery and reduces intensive care unit stay: A retrospective study of 124 patients. Eur J Surg Oncol [Internet]. 2016;42(12):1938–43. Available from: http://dx.doi.org/10.1016/j.ejso.2016.06.390
54. Brunner S, Mayer H, Blum K, Breidert M, Dietrich M, Dahl E, et al. Nutrition-related care needs of older patients in hospital: A qualitative multimethod study. Int J Nurs Knowl. 2023;34(2):148–60.
55. Mehrholz J, Thomas S, Burridge JH, Schmidt A, Scheffler B, Schellin R, et al. Fitness and mobility training in patients with Intensive Care Unit-acquired muscle weakness (FITonICU): Study protocol for a randomised controlled trial. Trials [Internet]. 2016;17(1):1–11. Available from: http://dx.doi.org/10.1186/s13063-016-1687-4
56. Tariq MI, Khan AA, Khalid Z, Farheen H, Siddiqi FA, Amjad I. Effect of early ≤ 3 Mets (Metabolic Equivalent of Tasks) of physical activity on patient’s outcome after cardiac surgery. J Coll Physicians Surg Pakistan [Internet]. 2017;27(8):490–4. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029376977&partnerID=40&md5=8d4e283df6c7c12039b75a9ad7641311
57. Black C, Grocott M, Singer M. The oxygen cost of rehabilitation interventions in mechanically ventilated patients: an observational study. Physiother (United Kingdom) [Internet]. 2020;107:169–75. Available from: https://doi.org/10.1016/j.physio.2019.06.008
58. Bordas-Martínez J, Luzardo-González A, Arencibia A, Tormo F, Matéu L, Vicens-Zygmunt V, et al. Effects of Early Physical Therapy and Follow-Up in Acute Severe Coronavirus Disease 2019 Pneumonia: A Retrospective Observational Study. Front Med [Internet]. 2022;9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85128826357&doi=10.3389%2Ffmed.2022.866055&partnerID=40&md5=bf26485a866269f33d391aa9609cc1c9
59. Elkbuli A, Fanfan D, Sutherland M, Newsome K, Morse J, Babcock J, et al. The Association Between Early Versus Late Physical Therapy Initiation and Outcomes of Trauma Patients With and Without Traumatic Brain Injuries. J Surg Res [Internet]. 2022;273:34–43. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123172016&doi=10.1016%2Fj.jss.2021.11.011&partnerID=40&md5=1d3dfcbbe0eee3dc5be4697f91171586
60. Schmidt K, Worrack S, Von Korff M, Davydow D, Brunkhorst F, Ehlert U, et al. Effect of a primary care management intervention on mental health-related qualityof life among survivors of sepsis a randomized clinical trial. JAMA - J Am Med Assoc. 2016;315(24):2703–11.
61. Swayngim R, Preslaski C, Dawson J. Use of Valproic Acid for the Management of Delirium and Agitation in the Intensive Care Unit. J Pharm Pract [Internet]. 2024;37(1):118–22. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85139070806&doi=10.1177%2F08971900221128636&partnerID=40&md5=d9708c9fd1824bc4c2283d21fe9cdb74
62. Rotolo D, Rafols I, Hopkins MM, Leydesdorff L. Strategic Intelligence on Emerging Technologies: Scientometric Overlay Mapping. J Assoc Inf Sci Technol. 2017;68(1):214–33.
63. Soto S, Adasme R, Vivanco P, Figueroa P. Efficacy of the «Start to move» protocol on functionality, ICU-acquired weakness and delirium: Randomized clinical trial. Med Intensiva [Internet]. 2024;48(4):211–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183543729&doi=10.1016%2Fj.medin.2023.12.001&partnerID=40&md5=45b20a9771739a53553637901fec785f
64. Lima LSS, de Medeiros Cardoso RA, dos Santos NP, de Almeida Silva BF, Borges MGB, Borges DL. Application of the ICU Mobility Scale in patients submitted to cardiac surgery. Fisioter em Mov. 2024;37.
65. Furstenau LB, Sott MK, Homrich AJO, Kipper LM, Dohan MS, López-Robles JR, et al. An Overview of 42 years of Lean Production: Applying Bibliometric Analysis to investigate strategic themes and scientific evolution structure. Technol Anal Strateg Manag [Internet]. 2021;33(9):1068–87. Available from: https://doi.org/10.1080/09537325.2020.1865530
66. Kumar S, Chavan M, Pandey N. Journal of International Management: A 25-year review using bibliometric analysis. J Int Manag [Internet]. 2023;29(1). Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85139261287&doi=10.1016%2Fj.intman.2022.100988&partnerID=40&md5=3dee28351e57c78304106628f8bcb4af
67. Bonizzoli M, Lazzeri C, Drago A, Tadini Boninsegni L, Donati M, Di Valvasone S, et al. Effects of a physiotherapic program in patients on veno-venous extracorporeal membrane oxygenation: An 8-year single-center experience. Minerva Anestesiol [Internet]. 2019;85(9):989–94. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072142909&doi=10.23736%2FS0375-9393.19.13287-7&partnerID=40&md5=b24d09d2d336d06611d4a84cecc8dc29
68. Ballesteros Reviriego G, Planas Pascual B, Rojo Ruiz A, Sánchez Romero EA, Corbelini C, Villafañe JH. Spanish Experience of Pulmonary Rehabilitation Efficacy for Patients Affected by the Novel SARS-CoV-2 (COVID-19): A Case Report. Top Geriatr Rehabil [Internet]. 2020;36(4):212–4. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096788753&doi=10.1097%2FTGR.0000000000000283&partnerID=40&md5=c5c241b10982f527ae83c7a4ac94dadc
69. Mahesh AH, Mahadevan R, Krishnarao CS. Impact of Physiotherapy on Functional Status and Length of Stay of Patients Admitted to Intensive Care Unit. Curr Respir Med Rev [Internet]. 2022;18(4):267–74. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85142610669&doi=10.2174%2F1573398X18666220818095151&partnerID=40&md5=54777e10d07ee85510d639309e404cb4
70. Di Leone CN, Diniz CP, Vieira de Araújo TM, Sant’ Anna MD, Lamas CDC, Mediano MFF, et al. Aerobic exercise simultaneous with non-invasive ventilation reduces the length of stay in intensive care in patients with heart failure: a randomised clinical trial. Eur J Physiother [Internet]. 2024;26(3):176–84. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164506674&doi=10.1080%2F21679169.2023.2229392&partnerID=40&md5=f6d8d863b6215a5e4378d507e0803d3f
71. Ferrara PE, Gatto DM, Bastoni I, Zordan P, Stefinlongo G, Marini R, et al. Rehabilitation of Children Affected by Congenital Posteromedial Bowing of the Tibia: A Case Report. J Biol Regul Homeost Agents [Internet]. 2022;36(3):769–74. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85144414467&doi=10.23812%2Fj.biol.regul.homeost.agents.20223603.84&partnerID=40&md5=80a9cf7401f553570eba6267d5c3152b
72. Varol BK, Tanrıverdi M, İşcan A, Alemdaroğlu-Gürbüz İ. The acute effects of physiotherapy on general movement patterns in preterm infants: A single-blind study. Early Hum Dev [Internet]. 2019;131:15–20. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061660776&doi=10.1016%2Fj.earlhumdev.2019.02.004&partnerID=40&md5=615371e7175ca0ade1aa97f3eaa0aa64
73. Eggmann S, Irincheeva I, Luder G, Verra ML, Moser A, Bastiaenen CHG, et al. Cardiorespiratory response to early rehabilitation in critically ill adults: A secondary analysis of a randomised controlled trial. PLoS One. 2022;17(2 February):1–16.
74. Jenkins TO, MacBean V, Poulsen MK, Karbing DS, Rees SE, Patel B V., et al. The metabolic cost of inspiratory muscle training in mechanically ventilated patients in critical care. Intensive Care Med Exp [Internet]. 2023;11(1). Available from: https://doi.org/10.1186/s40635-023-00522-6
75. Schujmann DS, Teixeira Gomes T, Lunardi AC, Zoccoler Lamano M, Fragoso A, Pimentel M, et al. Impact of a Progressive Mobility Program on the Functional Status, Respiratory, and Muscular Systems of ICU Patients: A Randomized and Controlled Trial. Crit Care Med. 2020;48(4):491–7.
76. Medrinal C, Prieur G, Bonnevie T, Gravier FE, Mayard D, Desmalles E, et al. Muscle weakness, functional capacities and recovery for COVID-19 ICU survivors. BMC Anesthesiol. 2021;21(1):1–5.
77. Nickels MR, Aitken LM, Walsham J, Crampton LJ, Barnett AG, McPhail SM. Exercise interventions are delayed in critically ill patients: a cohort study in an Australian tertiary intensive care unit. Physiother (United Kingdom) [Internet]. 2020;109:75–84. Available from: https://doi.org/10.1016/j.physio.2019.06.011
78. Amundadottir OR, Jónasdóttir RJ, Sigvaldason K, Gunnsteinsdottir E, Haraldsdottir B, Sveinsson T, et al. Effects of intensive upright mobilisation on outcomes of mechanically ventilated patients in the intensive care unit: a randomised controlled trial with 12-months follow-up. Eur J Physiother [Internet]. 2021;23(2):68–78. Available from: https://doi.org/10.1080/21679169.2019.1645880
79. Yosef-Brauner O, Adi N, Ben Shahar T, Yehezkel E, Carmeli E. Effect of physical therapy on muscle strength, respiratory muscles and functional parameters in patients with intensive care unit-acquired weakness. Clin Respir J. 2015;9(1):1–6.
80. van der Lee L, Hill AM, Patman S. A survey of clinicians regarding respiratory physiotherapy intervention for intubated and mechanically ventilated patients with community-acquired pneumonia. What is current practice in Australian ICUs? J Eval Clin Pract. 2017;23(4):812–20.
81. Sousa ML de A, Coimbra VR de M, Takei MT, Melo CC de A, Feltrim MIZ, Nozawa E. Physiological abnormalities and adverse events during physical therapy in the intensive care unit after cardiac surgery: A prospective observational study. Brazilian J Phys Ther. 2021;25(5):623–31.
82. Lorenz M, Fuest K, Ulm B, Grunow JJ, Warner L, Bald A, et al. The optimal dose of mobilisation therapy in the ICU: a prospective cohort study. J Intensive Care [Internet]. 2023;11(1):1–9. Available from: https://doi.org/10.1186/s40560-023-00703-1
83. Johnson AM, Henning AN, Morris PE, Tezanos AGV, Dupont-Versteegden EE. Timing and amount of physical therapy treatment are associated with length of stay in the cardiothoracic icu. Sci Rep [Internet]. 2017;7(1):1–9. Available from: http://dx.doi.org/10.1038/s41598-017-17624-3
84. Whitlock K, Rzewnicki D, Krieger B, Miller C, Creel-Bulos C. “Beyond waking and walking. Intensive rehabilitation in patients requiring extended durations of advanced mechanical circulatory support: A case series.” Perfus (United Kingdom) [Internet]. 2024;39(4):840–8. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85149475866&doi=10.1177%2F02676591231159570&partnerID=40&md5=7d9e8c75895f9c407a8106c7ff8528f8
85. Dionne A, Cavayas YA, Magnuson D, Richard-Denis A, Petit Y, Barthélémy D, et al. Is it safe to initiate activity-based therapy within days following traumatic spinal cord injury? Preliminary results from the PROMPT-SCI trial. J Spinal Cord Med [Internet]. 2023;46(6):980–5. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85166753659&doi=10.1080%2F10790268.2023.2212329&partnerID=40&md5=86458e5e523ce0f4b448a23c53e5b516